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Ketoconazole shampoo: effect of long-term use in androgenic alopecia.

Authors Pierard-Franchimont C.; De Doncker P.; Cauwenbergh G.; Pierard GE.

Institution Department of Dermatopathology, University of Liege, Belgium.

Source Dermatology. 196(4):474-7, 1998.

Abstract

BACKGROUND:

The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly.

OBJECTIVE:

The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia.

METHOD:

The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy.

RESULTS:

Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens.

The sebum casual level appeared to be decreased by KCZ.

CONCLUSION:

Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction.

The clinical significance of the results awaits further controlled study in a larger group of subjects.